PF-3450074 (PF-74) is a specifical inhibitor of HIV-1 capsid protein (CA) and displays a broad-spectrum inhibition of HIV isolates with submicromolar potency (EC50=8-640 nM). PF-3450074 (PF-74) acts at an early stage of HIV-1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle[1][2]. CPSF6: nuclear host factors cleavage and polyadenylation specific factor 6, NUP153: nucleoporin 153.
Molecular Weight:
425.52
Purity:
98.89
CAS Number:
[1352879-65-2]
Formula:
C27H27N3O2
Target:
HIV
Application Notes:
MCE Product type: Reference compound1
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