UNC1666 is an ATP-competitive dual-target Mer/Flt3 tyrosine kinase inhibitor with IC50 values of 0.55 nM and 0.69 nM, and Ki values of 0.16 nM and 0.67 nM, respectively. UNC1666 inhibits the kinase activities of Mer and Flt3, reduces their phosphorylation levels, suppresses downstream pro-survival signaling pathways (Erk1/2, Akt and Stat), induces cell apoptosis, and decreases colony formation of acute myeloid leukemia cells. UNC1666 is applicable to research related to acute myeloid leukemia[1][2].
Molecular Weight:
513.66
CAS Number:
[1429882-12-1]
Formula:
C26H35N5O4S
Target:
Akt,Apoptosis,ERK,FLT3,STAT
Application Notes:
MCE Product type: Reference compound1
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