GAT100 is a negative allosteric modulator and covalent allosteric probe for cannabinoid receptor type 1 (CB1R). GAT100 acts as a positive allosteric modulator for orthosteric agonist CP55,940 binding to regulate the CB1R signaling pathway. GAT100 reduces the potency and efficacy of orthosteric CB1R agonists in terms of beta-arrestin 1 recruitment, phosphorylation of PLCbeta3 and ERK1/2, cAMP accumulation, and CB1R internalization. GAT100 is applicable to the research of psychobehavioral and somatic diseases[1][2].
Molecular Weight:
432.59
CAS Number:
[1663564-42-8]
Formula:
C25H28N4OS
Target:
Cannabinoid Receptor,PERK
Application Notes:
MCE Product type: Reference compound1
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