AM-8508 is an orally bioactive PI3Kdelta inhibitor with an IC50 of 0.016 µM. AM-8508 selectively inhibits PI3Kdelta, thereby blocking AKT phosphorylation mediated by the B cell receptor. AM-8508 suppresses the formation of antigen-specific IgG and IgM in rats immunized with keyhole limpet hemocyanin. AM-8508 can be used for the research of inflammatory diseases[1].
Molecular Weight:
374.38
CAS Number:
[1338483-67-2]
Formula:
C19H15FN8
Target:
Akt,PI3K
Application Notes:
MCE Product type: Reference compound1
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