Metarrestin (ML246) is an orally active, first-in-class and specific perinucleolar compartment inhibitor. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2. Metarrestin blocks metastatic development and extends survival in mouse cancer models[1][2].
Molecular Weight:
474.60
Purity:
99.90
CAS Number:
[1443414-10-5]
Formula:
C31H30N4O
Target:
DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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