D-520 is a potent and brain-penetrant dopamine D2/D3 agonist (D2 EC50 = 4.73 nM, Ki = 41.8 nM, D3 EC50 = 2.18 nM, Ki = 0.35 nM). D-520 inhibits the formation of Abeta aggregates in vitro and promotes the disaggregation of both alpha-synuclein (alpha-syn) and Abeta aggregates. D-520 exhibits efficacious activity in animal models of Parkinsons disease (PD). D-520 can be used for PD and PD with dementia (PDD) research[1][2].
Molecular Weight:
501.66
CAS Number:
[1619269-47-4]
Formula:
C31H39N3O3
Target:
Amyloid-beta,Dopamine Receptor,alpha-synuclein
Application Notes:
MCE Product type: Reference compound
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