TASP0434299, CAS [[1520893-08-6]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-120247
Supplier Catalog Number:
HY-120247
Alternative Catalog Number:
MCE-HY-120247-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
TASP0434299 (Compound 10) is a radiolabeled ligand for the vasopressin V1b receptor. TASP0434299 exhibits high binding affinity for human and murine V1B receptors, with IC50 values of 0.526 nM and 0.641 nM, respectively, and shows potent antagonistic activity against the human V1B receptor with an IC50 of 0.639 nM. TASP0434299 is a substrate for human and rhesus monkey P-glycoprotein, resulting in low brain uptake in rhesus monkeys. TASP0434299 binds to V1B receptors in rat and monkey pituitary tissues in a saturable and specific manner both in vitro and in vivo. When radiolabeled with tritium or 11C, TASP0434299 serves as a prototype V1B receptor radiotracer to visualize V1B receptor in the pituitary gland of anesthetized monkeys via positron emission tomography[1][2][3].
Molecular Weight:
509.61
CAS Number:
[1520893-08-6]
Formula:
C27H35N5O5
Target:
P-glycoprotein,Vasopressin Receptor
Application Notes:
MCE Product type: Reference compound
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