PD98059 is a potent and selective MEK inhibitor with an IC50 of 5 µM. PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC50 of 2-7 µM) and MEK2 (IC50 of 50 µM) by upstream kinases. PD98059 is a ERK1/2 signaling inhibitor. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC50 of 4 µM) and AHR transformation (IC50 of 1 µM). PD98059 also inhibits Mycobacterium bovis Bacillus CalmetteGuerin (BCG)-induced autophagy[1][2][3].
Molecular Weight:
267.28
Purity:
99.96
CAS Number:
[167869-21-8]
Formula:
C16H13NO3
Target:
Aryl Hydrocarbon Receptor,Autophagy,ERK,MEK
Application Notes:
MCE Product type: Reference compound
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