ST-168 is an orally active MEK/PI3K inhibitor with an IC50 of 182 nM against MEK1 and IC50 values of 69.2, 41.7, 1482 and 2293 nM against PI3Kalpha, PI3Kdelta, PI3Kbeta and PI3Kgamma respectively. ST-168 completely inhibits the phosphorylation of ERK1/2 and AKT and induces cancer cell death in a 3D tumor sphere model. ST-168 demonstrates significant antitumor effects in the A375 melanoma mouse model. ST-168 improves the ocular toxicity profile of MEK inhibitors, showing lower caspase activation levels, indicating reduced apoptosis induction. ST-168 can be used in melanoma research[1][2].
Molecular Weight:
1010.75
CAS Number:
[2126038-25-1]
Formula:
C41H44F5IN10O7
Target:
Akt,Apoptosis,Caspase,MEK,PI3K
Application Notes:
MCE Product type: Reference compound
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