A-192621, a chemical probe, is a potent, nonpeptide, orally active and selective endothelin B (ETB) receptor antagonist with an IC50 of 4.5 nM and a Ki of 8.8 nM. The selectivity of A-192621 is 636-fold higher than ETA (IC50 of 4280 nM and Ki of 5600 nM). A-192621 promotes apoptosis in PASMCs. A-192621 alos causes elevation of arterial blood pressure and an elevation in the plasma ET-1 level[1][2][3].
Molecular Weight:
558.66
Purity:
99.85
CAS Number:
[195529-54-5]
Formula:
C33H38N2O6
Target:
Apoptosis,Endothelin Receptor
Application Notes:
MCE Product type: Reference compound1
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