DSR-71167 is an orally active mineralocorticoid receptor (MR) antagonist with an IC50 of 0.26 µM. DSR-71167 exhibits weak carbonic anhydrase (CA) inhibitory activity with an IC50 of 19 µM. DSR-71167 can dose-dependently increase urinary sodium excretion in rat models and has a very low risk of hyperkalemia in potassium-loading rat models. DSR-71167 lowers systolic blood pressure in hypertensive rat models. DSR-71167 can be used for research on hypertension and heart failure[1].
Molecular Weight:
529.96
CAS Number:
[1355687-91-0]
Formula:
C23H23ClF3N3O4S
Target:
Carbonic Anhydrase,Mineralocorticoid Receptor
Application Notes:
MCE Product type: Reference compound
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