AP14145 (hydrochloride), CAS [[2387505-59-9]] Preis auf Anfrage

Product Overview

• Article Name: AP14145 (hydrochloride), CAS [[2387505-59-9]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-120355A
• Supplier Catalog Number: HY-120355A
• Alternative Catalog Number: MCE-HY-120355A-5MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

AP14145 hydrochloride is a potent KCa2 (SK) channel negative allosteric modulator with an IC50 of 1.1 µM for KCa2.2 (SK2) and KCa2.3 (SK3) channels. AP14145 hydrochloride inhibition strongly depends on two amino acids, S508 and A533 in the channel. AP14145 hydrochloride prolonged atrial effective refractory period (AERP) in rats and demonstrates antiarrhythmic effects in a Vernakalant-resistant porcine model of atrial fibrillation (AF)[1][2].

Product Properties

• Molecular Weight: 398.81
• Purity: 98.3
• CAS Number: [2387505-59-9]
• Formula: C18H18ClF3N4O
• Target: Potassium Channel

Application Notes

• Application Notes: MCE Product type: Reference compound