T-1101 (TAI-95) is an orally active inhibitor for mitose regulating highly expressed oncoprotein 1 (Hec1). T-1101 blocks the interaction between Hec1 and NEK2, exhibits cytotoxicity in human liver cancer cells with GI50 of 15-70 nM. T-1101 induces apoptosis in Huh-7. T-1101 exhibits antitumor efficacy in mouse models[1].
Molecular Weight:
493.60
CAS Number:
[1438638-83-5]
Formula:
C24H23N5O3S2
Target:
Apoptosis,NEKs
Application Notes:
MCE Product type: Reference compound
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