T-1101 tosylate (TAI-95 tosylate) is the tosylate salt form of T-1101 (HY-120356). T-1101 tosylate is an orally active inhibitor for mitose regulating highly expressed oncoprotein 1 (Hec1). T-1101 tosylate blocks the interaction between Hec1 and NEK2, exhibits cytotoxicity in human liver cancer cells with GI50 of 15-70 nM. T-1101 tosylate induces apoptosis in Huh-7. T-1101 tosylate exhibits antitumor efficacy in mouse models[1].
Molecular Weight:
665.80
Purity:
98.91
CAS Number:
[2250404-95-4]
Formula:
C31H31N5O6S3
Target:
Apoptosis,NEKs
Application Notes:
MCE Product type: Reference compound1
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