Rigosertib sodium (ON-01910 sodium) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3K/Akt pathway, promotes the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle[1][2]. Rigosertib sodium is a selective and non-ATP-competitive inhibitor of PLK1 with an IC50 of 9 nM[3].
Molecular Weight:
473.47
Purity:
99.57
CAS Number:
[592542-60-4]
Formula:
C21H24NNaO8S
Target:
Apoptosis,PI3K,Polo-like Kinase (PLK)
Application Notes:
MCE Product type: Reference compound
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