BMS-871 is an orally active pan-Notch inhibitor with IC50 values of 4/1/4/3 nM for Notch1/2/3/4, respectively. BMS-871 significantly inhibited the proliferation of TALL-1 and MDA-MB-157 cells and demonstrated significant antitumor activity in T-acute lymphoblastic leukemia and triple-negative breast cancer xenograft models. BMS-871 can be used to study leukemia and breast cancer[1].
Molecular Weight:
536.54
CAS Number:
[1584631-89-9]
Formula:
C29H27F3N4O3
Target:
Notch
Application Notes:
MCE Product type: Reference compound
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