Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis). Elesclomol specifically binds ferredoxin 1 (FDX1) alpha2/alpha3 helices and beta5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research[1][2][3][4].
Molecular Weight:
400.52
Purity:
99.43
CAS Number:
[488832-69-5]
Formula:
C19H20N4O2S2
Target:
Apoptosis,Cuproptosis,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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