SKLB188 is an orally active and potent epidermal growth factor receptor (EGFR) inhibitor (IC50=5 nM). SKLB188 suppresses MEK/Erk and Akt/mTOR signaling pathways to inhibit head and neck squamous cell carcinoma (HNSCC) proliferation and induce caspase-dependent apoptosis. SKLB188 is promising for research of EGFR-overexpressing solid tumors[1].
Molecular Weight:
513.59
CAS Number:
[1350545-09-3]
Formula:
C27H31N9O2
Target:
Apoptosis,EGFR
Application Notes:
MCE Product type: Reference compound
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