JP-153 is the Src-FAK-Paxillin signaling inhibitor. JP-153 inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473). JP-153 reduces VEGF-induced migration and proliferation in retinal endothelial cells. JP-153 can be uesd for the study of neovascular eye disease[1].
Molecular Weight:
365.38
Purity:
99.45
CAS Number:
[1802937-26-3]
Formula:
C21H19NO5
Target:
FAK,Src
Application Notes:
MCE Product type: Reference compound
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