Cosalane (NSC 658586) is a CCR7 (IC50 = 2.43 µM) and CXCR2 antagonist (IC50 = 0.66 µM). Cosalane is an inhibitor of HIV replication with a wide range of activity against HIV-1 isolates, HIV-2, Rauscher murine leukemia virus, HSV-1, HSV-2 and human cytomegalovirus. Cosalane inhibits both attachment of gp120 to CD4. Cosalane inhibits human and murine CCR7 in response to both CCL19 and CCL21 agonists. Cosalane can be studied in research for HIV or attenuating acute graft-versus-host disease (aGVHD) in allogeneic hematopoietic stem cell transplantation (HSCT)[1][2][3][4][5].
Molecular Weight:
767.86
Purity:
99.78
CAS Number:
[154212-56-3]
Formula:
C45H60Cl2O6
Target:
CCR,CXCR,HIV,HSV
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
