AM-0687 is a selective inhibitor for PI3Kdelta with an IC50 of 2.9 nM. AM-0687 decreases the levels of IgG and IgM specific antibodies, inhibits the anti-IgM/CD40L-induced proliferation of human B cell (IC50=0.8 nM) and the phosphorylation of AKT (IC50=0.7 nM), and exhibits anti-inflammatory efficacy[1].
Molecular Weight:
442.45
CAS Number:
[1259522-94-5]
Formula:
C23H19FN8O
Target:
PI3K
Application Notes:
MCE Product type: Reference compound
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