A-1048400 is an orally active and selective calcium channel inhibitor with an IC50 value of 1.4 µM for N-type channels, 1.2 µM for T-type channel. A-1048400 inhibits neurotransmitter release and reduces membrane hyperexcitability, exerting potent analgesic activity. A-1048400 is promising for research of neuropathic pain (e.g., pain induced by spinal nerve ligation and chronic constriction injury)[1].
Molecular Weight:
543.70
CAS Number:
[1219624-62-0]
Formula:
C36H37N3O2
Target:
Calcium Channel
Application Notes:
MCE Product type: Reference compound1
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