KNT-127 is a selective and BBB-penetrant delta-opioid receptor (DOR) agonist (Ki = 0.16 nM). KNT-127 is highly selective to the delta receptor, with Ki values of 0.16, 21.3 and 153 nM for delta, µ and kappa receptors, respectively. KNT-127 acts as a biased ligand that mainly activates cyclic adenosine monophosphate (cAMP) signaling with lower beta-arrestin signaling activation. KNT-127 increases the release of dopamine and L-glutamate in the striatum, nucleus accumbens, and prefrontal cortex. KNT-127 exhibits antidepressant- and anxiolytic-like effects. KNT-127 can be studied in research on neurological diseases[1][2][3][4][5].
Molecular Weight:
372.46
Purity:
99.11
CAS Number:
[1256921-89-7]
Formula:
C24H24N2O2
Target:
Opioid Receptor
Application Notes:
MCE Product type: Reference compound1
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