B355252, a phenoxy thiophene sulfonamide small molecule, is a potent NGF receptor agonist. B355252 potentiates NGF-induced neurite outgrowth. B355252 protects ischemic neurons from neuronal loss by attenuating DNA damage, reducing ROS production and the LDH level, and preventing neuronal apoptosis. B355252 has anti-apoptotic effects in glutamate-induced excitotoxicity, as well as in a murine hippocampal cell line (HT22) model of Parkinson disease (PD)[1].
Molecular Weight:
514.06
Purity:
99
CAS Number:
[1261576-81-1]
Formula:
C25H24ClN3O3S2
Target:
Apoptosis
Application Notes:
MCE Product type: Reference compound
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