PC-046 is a multi-target inhibitor for tyrosine receptor kinase B (TrkB), IRAK-4 and Pim-1, with IC50 of 13.4 µM, 15.4 µM and 19.1 µM, respectively. PC-046 exhibits cytotoxicity against pancreatic cancer cell BxPC3 with IC50 of 7.5-130 nM. PC-046 induces apoptosis and arrests cell cycle at G2/M phase in BxPC3. PC-046 exhibits antitumor efficacy and exhibits good pharmacokinetic characteristics in mice[1].
Molecular Weight:
358.39
CAS Number:
[1202401-59-9]
Formula:
C22H18N2O3
Target:
Apoptosis,IRAK,Pim,Trk Receptor
Application Notes:
MCE Product type: Reference compound
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