WB403 is an orally active TGR5 activator with an EC50 of 5.5 µM against human TGR5. WB403 activates TGR5 to stimulate downstream signaling pathways, promote GLP-1 secretion, improve glucose tolerance in mice with type 2 diabetes, and reduce levels of fasting blood glucose, postprandial blood glucose and HbA1c. WB403 increases pancreatic beta-cell mass and restores the distribution of alpha-cells and beta-cells in islets. WB403 is applicable to the research of type 2 diabetes[1].
Molecular Weight:
403.34
Purity:
99.16
CAS Number:
[1594041-84-5]
Formula:
C19H19BrN2OS
Target:
G protein-coupled Bile Acid Receptor 1
Application Notes:
MCE Product type: Reference compound1
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