BMS-986122 is a selective, potent positive allosteric modulator of the mu-opioid receptor (µ-OR). BMS-986122 shows potentiation of orthosteric agonist-mediated beta-arrestin recruitment, adenylyl cyclase inhibition, and G protein activation. BMS-986122 potentiates DAMGO-mediated [35S]GTPgammaS binding in mouse brain membranes[1][2].
Molecular Weight:
448.78
Purity:
99.90
CAS Number:
[313669-88-4]
Formula:
C16H15BrClNO3S2
Target:
Opioid Receptor
Application Notes:
MCE Product type: Reference compound1
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