DS-5272 is an orally acitve inhibitor for p53-MDM2 with an IC50 of 20 nM. DS-5272 inhibits the proliferation of SJSA-1 (wildtype p53, IC50=0.17 µM) and DLD-1 (mutant p53). DS-5272 arrest the cell cycle, and induces apoptosis in SJSA-1. DS-5272 exhibits antitumor efficacy in mice[1].
Molecular Weight:
703.67
CAS Number:
[1235575-97-9]
Formula:
C34H38Cl2F2N6O2S
Target:
Apoptosis,MDM-2/p53
Application Notes:
MCE Product type: Reference compound
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