R406 is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value. R406 reduces immune complex-mediated inflammation[1]. R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM)[2].
Molecular Weight:
628.63
Purity:
96.70
CAS Number:
[841290-81-1]
Formula:
C28H29FN6O8S
Target:
Apoptosis,FLT3,Syk
Application Notes:
Reference compound
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