TROX-1 is a selective, orally active and brain-penetrant N-type calcium channel (Cav2.2) inhibitor with an IC50 value of 0.11 µM. TROX-1 exerts state-dependent and use-dependent inhibition, preferentially targets open/inactivated channels, blocks depolarization-associated calcium influx, and fully blocks calcium influx in rat dorsal root ganglion neurons. TROX-1 reverses inflammatory-induced hyperalgesia, nerve injury-induced allodynia. TROX-1 can be used for the research of pain[1][2].
Molecular Weight:
434.85
Purity:
99.55
CAS Number:
[1309601-26-0]
Formula:
C22H16ClFN6O
Target:
Calcium Channel
Application Notes:
MCE Product type: Reference compound
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