CMC2.24 (TRB-N0224), an orally active tricarbonylmethane agent, is effective against pancreatic tumor in mice by inhibiting Ras activation and its downstream effector ERK1/2 pathway. CMC2.24 is also a potent inhibitor of zinc-dependent MMPs with IC50s ranging from 2.0-69 µM. CMC2.24 alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-kappaB/HIF-2alpha axis[1][2][3].
Molecular Weight:
427.45
Purity:
97.48
CAS Number:
[1255639-43-0]
Formula:
C26H21NO5
Target:
Apoptosis,MMP,Ras
Application Notes:
Reference compound
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