PPY-A is a potent T315I mutant and wild-type Abl kinases inhibitor with IC50s of 9 and 20 nM, respectively. PPY-A inhibits Ba F3 cells transformed with wild-type Abl and Abl T315I mutantl with IC50s of 390 and 180 nM, respectively. PPY-A can be used for the research of chronic myeloid leukemia (CML)[1].
Molecular Weight:
372.42
Purity:
98.02
CAS Number:
[875634-01-8]
Formula:
C22H20N4O2
Target:
Bcr-Abl
Application Notes:
MCE Product type: Reference compound
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