BI 186908 is a selective and orally active MCH receptor 1 antagonist with an IC50 of 22 nM and a Ki of 14 nM. BI 186908 binds with comparably high affinity to the recombinant human, cynomolgus monkey (IC50 of 18 nM), dog (IC50 of 23 nM) and rat (IC50 of 18 nM) MCH-R1. BI 186908 can significantly reduce the body weight of diet-induced obese rats. BI 186908 can be used for the study of obesity[1].
Molecular Weight:
422.48
CAS Number:
[1453500-36-1]
Formula:
C23H26N4O4
Target:
MCHR1 (GPR24)
Application Notes:
MCE Product type: Reference compound
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