CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist (IC50=5.2 nM/1 nM in beta-arrestin assay/CXCR2 Tango assay, respectively). CXCR2-IN-2 displays ~730-fold selectivity over CXCR1 and >1900-fold selectivity over all other chemokine receptors. CXCR2-IN-2 inhibits human whole blood Gro-alpha induced CD11b expression with an IC50 of 0.04 µM[1].
Molecular Weight:
414.90
Purity:
99.52
CAS Number:
[1838123-21-9]
Formula:
C18H23ClN2O5S
Target:
CXCR
Application Notes:
MCE Product type: Reference compound
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