GUT-70, a tricyclic coumarin, is a Hsp90 inhibitor. GUT-70 activates the caspase 2, 3, 8 and 9, and induces the apoptosis in leukemic cells. GUT-70 inhibits HIV-1 replication in chronically infected cells via suppression of the NF-kappaB pathway. GUT-70 can be used for the study of leukemic, mantle cell lymphoma (MCL) and HIV-1 infection[1][2][3].
Molecular Weight:
382.45
CAS Number:
[161633-75-6]
Formula:
C23H26O5
Target:
Apoptosis,Caspase,HIV,HSP,NF-kappaB
Application Notes:
MCE Product type: Reference compound
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