7BIO (7-Bromoindirubin-3-Oxime) is the derivate of indirubin. 7BIO (7-Bromoindirubin-3-Oxime) has inhibitory effects against cyclin-dependent kinase-5 (CDK5) and glycogen synthase kinase-3beta (GSK3beta). 7BIO (7-Bromoindirubin-3-Oxime) inhibits Abeta oligomer-induced neuroinflammation, synaptic impairments, tau hyper-phosphorylation, activation of astrocytes and microglia, and attenuates Abeta oligomer-induced cognitive impairments in mice[1].
Molecular Weight:
356.17
Purity:
99.20
CAS Number:
[916440-85-2]
Formula:
C16H10BrN3O2
Target:
CDK,GSK-3
Application Notes:
MCE Product type: Reference compound
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