S 1360 is a potent and selective inhibitor of HIV-1 integrase. S 1360 inhibits the catalytic activity of purified integrase ( IC50: 20 nM). The EC50, and CC50 of S 1360 in MTT assay (MT-4 cells infected with HIV-1 IIIB) are 200 nM and 12 µM, respectively. S 1360 has antiviral activity against both X4 tropic and R5 tropic strains, as well as NRTI, NNRTI and PI drug-resistant variants[1].
Molecular Weight:
313.28
CAS Number:
[280571-30-4]
Formula:
C16H12FN3O3
Target:
HIV,HIV Integrase
Application Notes:
MCE Product type: Reference compound
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