1,8-Dihydroxy-4,5-dinitroanthraquinone (ARDP0006, DHDNE) is a potent inhibitor of serine proteinase NS2B/3, the dengue viral protein. 1,8-Dihydroxy-4,5-dinitroanthraquinone has intermolecular proteinase activity and viral inhibition ability with IC50s of 432 µM and 4.2 µM, respectively. Meanwhile 1,8-Dihydroxy-4,5-dinitroanthraquinone inhibits NS2B/3 cleavage in BHK-21 cells at a dose ranging from 4.2 µM to 432 µM[1].
Molecular Weight:
330.21
Purity:
98.03
CAS Number:
[81-55-0]
Formula:
C14H6N2O8
Target:
Dengue Virus,Flavivirus,Virus Protease
Application Notes:
MCE Product type: Reference compound1
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