1,4-DPCA, a potent prolyl-4-hydroxylase inhibitor, is a collagen hydroxylation inhibitor in human foreskin fibroblasts with an IC50 of 2.4 µM. 1,4-DPCA inhibits prolyl-4-hydroxylases alpha isoforms stabilizes HIF-1alpha protein. 1,4-DPCA also inhibits factor inhibiting HIF (FIH) with an IC50 of 60 µM[1][2].
Molecular Weight:
240.21
Purity:
98.36
CAS Number:
[331830-20-7]
Formula:
C13H8N2O3
Target:
HIF/HIF Prolyl-Hydroxylase
Application Notes:
Reference compound
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