GW274150 is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 µM, Kd=40 nM) and rat iNOS (ED50=1.15 µM). GW274150 also displays less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS). GW274150 exerts a protective role in an acute model of lung injury inflammation[1][2].
Molecular Weight:
219.30
Purity:
98.42
CAS Number:
[210354-22-6]
Formula:
C8H17N3O2S
Target:
NO Synthase
Application Notes:
MCE Product type: Reference compound1
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