Apalcillin (PC-904) in combination with Ro 48-1220, a penam sulfone beta-lactamase inhibitor, demonstrated broad-spectrum activity against gram-negative aerobic and anaerobic bacteria, excluding Klebsiella oxytoca. It exhibited potent activity against beta-lactamase-producing Moraxella catarrhalis, Haemophilus influenzae, and Neisseria gonorrhoeae, with effective MICs (11 µg/mL). The combination also inhibited Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter species at low MICs (0.25 to 4 µg/mL). However, its efficacy against oxacillin-resistant staphylococci and certain gram-positive organisms was limited. Apalcillin/Ro 48-1220 showed comparable efficacy to piperacillin/tazobactam against some extended-spectrum beta-lactamase-producing Escherichia coli but was less effective against SHV-type beta-lactamases[1].
Molecular Weight:
521.55
CAS Number:
[63469-19-2]
Formula:
C25H23N5O6S
Target:
Bacterial
Application Notes:
MCE Product type: Reference compound1
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