GW274150 phosphate is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 µM, Kd=40 nM) and rat iNOS (ED50=1.15 µM). GW274150 phosphate displays less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS). GW274150 phosphate exerts a protective role in an acute model of lung injury inflammation[1][2].
Molecular Weight:
317.30
Purity:
98.02
CAS Number:
[438542-15-5]
Formula:
C8H20N3O6PS
Target:
NO Synthase
Application Notes:
MCE Product type: Reference compound
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