Poloxipan is a pan-specific polo-like kinase (PLK) inhibitor that can inhibit a non-catalytic region at the C-terminus called the Polo-box domain (PBD) found in kinases. The IC50 values for Poloxipan against the PBDs of PLK-1/2/3 are 3.2 µM, 1.7 µM, and 3.0 µM, respectively. Poloxipan also inhibits other phospho-tyrosine binding domains, such as the forkhead-associated (FHA) domain of CHK-2, the WW domain of peptidyl-prolyl cis/trans isomerase (PIN1), and the phospho-tyrosine binding domains of STAT1/3/5 and lymphocyte-specific protein tyrosine kinases SH2 domain. Poloxipan can be used in cancer research[1].
Molecular Weight:
380.22
CAS Number:
[1239513-63-3]
Formula:
C14H10BrN3O3S
Target:
PIN1,Polo-like Kinase (PLK),STAT
Application Notes:
MCE Product type: Reference compound1
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