CP-99994 is a Tachykinin neurokinin 1 (NK-1) receptor antagonist with a Ki of 0.25 nM. CP-99994 prevents colorectal sensitization in the context of visceral hypersensitivity. CP-99994 reduces colorectal hypersensitivity induced by acetic acid injections in a model of bladder-colon cross-sensitization. CP-99994 hydrochloride attenuates the neuroglial interactions and MAPK-p38 phosphorylation associated with visceral hypersensitivity[1].
Molecular Weight:
296.41
CAS Number:
[136982-36-0]
Formula:
C19H24N2O
Target:
Neurokinin Receptor,p38 MAPK
Application Notes:
MCE Product type: Reference compound2
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