Stearoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin. Arachidonoyl serotonin is a dual antagonist of fatty acid amide hydrolase (FAAH) and the transient receptor potential vanilloid-type 1 (TRPV1) channel, reducing both acute and chronic peripheral pain. The effects of replacing the arachidonoyl portion with the saturated 18-carbon stearoyl moiety have not been studied. However, replacement of arachidonate with saturated 11- or 12-carbon fatty acids produces compounds that potently inhibit capsaicin-induced TRPV1 channel activation (IC50=0.76 µM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC50 > 50 µM).
Molecular Weight:
442.68
CAS Number:
[67964-87-8]
Formula:
C28H46N2O2
Target:
Endogenous Metabolite
Application Notes:
MCE Product type: Reference compound
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