(5Z,2E)-CU-3 is a potent and selective inhibitor against the alpha-isozyme of DGK with an IC50 value of 0.6 µM, competitively inhibits the affinity of DGKalpha for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKalpha. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1].
Molecular Weight:
392.47
Purity:
98.04
CAS Number:
[1815598-71-0]
Formula:
C16H12N2O4S3
Target:
Apoptosis,DGK
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
