MK-8141 (ACT-077825) is a renin inhibitor that significantly increases levels of immunoreactive renin (ir-AR) by sevenfold but does not result in sustained reductions in blood renin activity (PRA). This study evaluated the antihypertensive efficacy of MK-8141 in hypertensive disease. Despite its effects on ir-AR, MK-8141 (ACT-077825) did not produce significant blood pressure-lowering effects in the absence of sustained PRA inhibition.
Molecular Weight:
620.61
CAS Number:
[903579-36-2]
Formula:
C35H39Cl2N3O3
Target:
Renin
Application Notes:
MCE Product type: Reference compound
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