Dynarrestin is an aminothiazole inhibitor of cytoplasmic dynein (cytoplasmic dynein) 1 and 2 and can be used to probe cytoplasmic dynein-dependent cellular processes. Dynarrestin rapidly and reversibly inhibits dynamin-1-driven microtubule sliding in vitro and disrupts mitosis by inducing spindles. Dynarrestin does not affect ATP hydrolysis and interferes with ciliogenesis. Dynarrestin inhibits hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells.
Molecular Weight:
431.50
Purity:
98.18
CAS Number:
[2222768-84-3]
Formula:
C22H23F2N3O2S
Target:
Hedgehog
Application Notes:
MCE Product type: Reference compound
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