iGP-1 is a cell-permeable, selective mixed inhibitor of mitochondrial sn-glycerol-3-phosphate dehydrogenase (mGPDH), with IC50s of 6.3 µM and 13.6 µM for rat mGPDH activity and H2O2 production, respectively. iGP-1 specifically blocks the mitochondrial component of the glycerophosphate shuttle without affecting cytosolic GPDH. iGP-1 not only inhibits cell proliferation and glutaminolysis, and enhances glycolysis, but also significantly alters key cellular physiological processes such as apoptosis, ROS production, HIF-1alpha stability and mitochondrial membrane potential. iGP-1 remains active in neutrophil cultures under both normoxic and hypoxic conditions, and serves as an ideal probe for glycerol-3-phosphate metabolic mechanisms. iGP-1 has been applied to studies on prostate cancer and related metabolic pathways[1][2][3].
Molecular Weight:
309.32
Purity:
99.43
CAS Number:
[27031-00-1]
Formula:
C17H15N3O3
Target:
HIF/HIF Prolyl-Hydroxylase,Phosphoglycerate Dehydrogenase (PHGDH),Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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