Binucleine 2, CAS [[220088-42-6]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-121998
Supplier Catalog Number:
HY-121998
Alternative Catalog Number:
MCE-HY-121998-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Binucleine 2 is an isoform-specific and ATP-competitive inhibitor of Drosophila Aurora B kinase (Ki=0.36 µM), a kinase involved in cell division. It is specific for Drosophila Aurora B kinase, inhibiting it in a dose-dependent manner, with minimal inhibition of human or X. laevis Aurora B kinases at concentrations up to 100 µM. Binucleine 2 induces mitotic and cytokinesis defects in Drosophila Kc167 cells. It prevents Drosophila S2 cells from assembling a contractile ring during cell division when used at a concentration of 40 µM but does not affect ring ingression, suggesting that Aurora B kinase activity is not required for that step.
Molecular Weight:
291.71
CAS Number:
[220088-42-6]
Formula:
C13H11ClFN5
Target:
Aurora Kinase
Application Notes:
MCE Product type: Reference compound
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